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 2006-03-19 06:00:00
 Diet rendah karbohidrat efektif untuk menurunkan berat badan
 Arch Intern Med. 2006;166:285-293. February 13, 2006. © 2006 American Medical Association. All rights reserved.
Effects of Low-Carbohydrate vs Low-Fat Diets on Weight Loss and Cardiovascular Risk Factors - A Meta-analysis of Randomized Controlled Trials, Alain J. Nordmann, MD, MSc; Abigail Nordmann, BS; Matthias Briel, MD; Ulrich Keller, MD; William S. Yancy, Jr, MD, MSH; Bonnie J. Brehm, PhD; Heiner C. Bucher, MD, MPH
Penelitian ini membuktikan bahwa untuk menurunkan berat badan diet rendah karbohidrat tanpa pembatasan energi sama efektif dengan diet rendah lemak disertai pembatasan energi. Diet rendah karbohidrat menghasilkan penurunan trigliserida dan peningkatan kolesterol HDL, namun harus dipertimbangkan peningkatan kolesterol total dan LDL.
Although low-carbohydrate diets have become increasingly popular for weight loss, evidence from individual trials about benefits and risks of these diets to achieve weight loss and modify cardiovascular risk factors is incomplete. Swiss and US researchers used the Cochrane Collaboration search strategy to identify trials comparing the effects of low-carbohydrate diets without restriction of energy intake vs low-fat diets in individuals with a body mass index (calculated as weight in kilograms divided by the square of height in meters) of at least 25. Included trials had to report changes in body weight in intention-to-treat analysis and to have a follow-up of at least 6 months.

They found that 5 trials including a total of 447 individuals fulfilled the inclusion criteria. After 6 months, individuals assigned to low-carbohydrate diets had lost more weight than individuals randomized to low-fat diets (weighted mean difference, 3.3 kg). This difference was no longer obvious after 12 months (weighted mean difference, 1.0 kg). There were no differences in blood pressure. Triglyceride and high-density lipoprotein cholesterol values changed more favorably in individuals assigned to low-carbohydrate diets (after 6 months, for triglycerides, weighted mean difference, 22.1 mg/dL [0.25 mmol/L]; and for high-density lipoprotein cholesterol, weighted mean difference, 4.6 mg/dL [0.12 mmol/L]), but total cholesterol and low-density lipoprotein cholesterol values changed more favorably in individuals assigned to low-fat diets (weighted mean difference in low-density lipoprotein cholesterol after 6 months, 5.4 mg/dL [0.14 mmol/L]).





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